
-documented ability to act synergistically with cytotoxic agents. We recently showed that the HDACi valproic acid sensitizes osteosarcoma cells to doxorubicin in vitro and in vivo . As there are no published reports...

The anti-epileptic drug valproic acid (VPA) has attracted attention as an anti-cancer agent. Methods: The present study investigated effects of VPA exposure on histone deacetylase (HDAC) inhibition, cell growth...

problem in gastric cancer. This study was performed to investigate the inhibitory effects of valproic acid (VPA) on a highly peritoneal-seeding cell line of human scirrhous gastric cancer, OCUM-2MD3, and to explore...

Background/aim To examine the efficacy and safety of valproic acid (VPA) in patients with retinitis pigmentosa (RP). Methods Thirteen eyes were examined before and after brief treatment (average 4 months) with VPA...

Valproic acid, an epilepsy drug also used to treat bipolar disorder, may have benefits against Alzheimer's disease if given before Alzheimer's gets severe, a new study shows. Researchers report that mice genetically...

and cell biology at UMMS, and his team, describe a potential new therapeutic link between valproic acid and RP, which could have tremendous benefits for patients suffering from the disease. In a retrospective study...

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Women with epilepsy who take valproic acid during the first trimester of pregnancy are more likely to have children with birth defects than women who took other epilepsy drugs or no medicine to control their seizure...

activity and the underlying molecular mechanisms associated with cytarabine combined with valproic acid (VPA; a histone deacetylase inhibitor and a Food and Drug Administration

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